Ruboxistaurin Hydrochloride

Name	Ruboxistaurin Hydrochloride
Synonyms	Ruboxistaurin HCl Ruboxistaurin(LY333531HCl) RUBOXISTAURIN HYDROCHLORIDE Ruboxistaurin Hydrochloride Ruboxistaurin HCl(LY333531 ) Ruboxistaurin hydrochloride (LY333531) LY 333531 hydrochloride - Ruboxistaurin
CAS	169939-93-9

Molecular Formula	C28H29ClN4O3
Molar Mass	505.01
Specific Rotation(α)	D25 -28.7° (c = 1.0 in ethanol)
Solubility	DMSO: soluble10mg/mL, clear
Appearance	powder
Color	orange-red
Storage Condition	Inert atmosphere,Store in freezer, under -20°C
In vitro study	LY333531 significantly reduced the chance of HUVEC cell survival, and the effect of LY333531 on apoptotic cell death of HUVEC was significantly increased compared to the AGEs Group. Inhibition of PKC-beta could increase the expression level of Bax and Bad protein, and decrease the expression level of Bcl-2 protein. In addition, LY333531 decreased the ratio of Bcl-2/Bax. It promotes AGEs-induced endothelial cell apoptosis. The upregulation of Bax, Bad expression and Bcl-2, and the decrease of Bcl2/Bax ratio were all related to the apoptotic process.
In vivo study	In streptozotocin-induced diabetic rats, 4 weeks of LY333531 treatment prevented the overactivation of PKCb2 and alleviated diastolic dysfunction. LY333531 inhibited the decreased expression of NO, Cav-2, p-AKT, p-eNOS and decreased the increased expression of O2-, nitrotyrosine, Cav-1, iNOS in myocardium.

WGK Germany

Last Update：2024-01-02 23:10:35

Product Name: Ruboxistaurin Hydrochloride Visit Supplier Webpage Request for quotation
CAS: 169939-93-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Product Name: Ruboxistaurin Hydrochloride Visit Supplier Webpage Request for quotation
CAS: 169939-93-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

Ruboxistaurin Hydrochloride

Ruboxistaurin Hydrochloride Request for Quotation